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. Author manuscript; available in PMC: 2015 Sep 7.
Published in final edited form as: Cell Transplant. 2014 Mar 7;24(8):1599–1614. doi: 10.3727/096368914X678571

Figure 8.

Figure 8

Model of the role of TIM4+ B-cells in the alloimmune response in islet transplantation. TIM4 B-cells in normal conditions inhibits the Th2 immune response (A). TIM4 targeting with RMT4-53 enhances the Th2 response (B). In the absence of a Th1 response (as in Tbet−/− mice), TIM4 still exerts a Th2 inhibitory effect (C), and TIM4 targeting with RMT4-53 enhances the Th2 response (D). In the absence of B-cells, an increased Th2 response is evident due to the lack of TIM4 inhibition (E), and TIM4 targeting with RMT4-53 does not further increase Th2 response (F).