Table 1.
Patients’ data prior to treatment with ESAs*
| Patient no. | Age, years | Sex | Interval to first admission | DAT prior to / post ESAs | Erythropoietin (4.3–29 U/l) | Diagnosis | |||
|---|---|---|---|---|---|---|---|---|---|
| IgG | IgM | IgA | C3d | ||||||
| 1* | 76 | m | 15 years | 4+ / 3+ | – / – | – / – | – / – | n.t. | WAIHA |
| 2* | 55 | f | few days | 1+ / – | – / – | – / – | 1+ / – | n.t. | WAIHA |
| 3 | 79 | f | 2 years | 4+ / 4+ | – / – | – / – | 1+ / 1+ | 16.7 | WAIHA, CLL |
| 4 | 35 | m | few days | 2+ / – | – / – | – / – | 2+ / – | n.t. | WAIHA |
| 36 | m | 1 year | – / – | – / – | 4+ / 3+ | – / – | 37.7 | WAIHA | |
| 5 | 80 | f | 17 years | 4+ / 1+ | – / – | – / – | 3+ / 1+ | n.t. | WAIHA |
| 6 | 78 | f | 2 years | 4+ / 4+ | – / – | – / – | – / – | n.t. | WAIHA |
| 7 | 52 | f | 3 months | 4+ / 2+ | – / – | – / – | – / – | 59.2 | WAIHA |
| 8 | 75 | m | > years | – / – | – / – | – / – | 4+ / 4+ | n.t. | CAIHA |
| 9 | 62 | m | > 15 years | – / – | – / – | – / – | 4+ / 4+ | 210 | CAIHA, lymphoma |
| 10 | 90 | f | many years | – / – | – / – | – / – | 4+ / 4+ | n.t. | CAIHA |
| 11 | 80 | f | > 4 years | – / – | – / – | – / – | 4+ / 4+ | 62.9 | CAIHA |
| 12 | 58 | f | > 3 years | – / – | – / – | – / – | 4+ / 4+ | 60.0 | CAIHA |
DAT = Direct antiglobulin test; CLL = chronic lymphocytic leukemia; n.t. = not tested.
*
Prior to treatment, histological investigations demonstrated increased erythropoiesis in all cases.