Table 1.
Solubility studies of HCT in various vehicles.
| Vehicle | Function in SNEDDS | Solubility (mg/mL) |
|---|---|---|
| Maisine 35-1 | Oil | 1.97 ± 0.7 |
| Oleic acid | Oil | 2.65 ± 0.85 |
| Capmul MCM | Oil | 3.43 ± 0.54 |
| Castor oil | Oil | 1.68 ± 0.54 |
| Captex 355 EP/NF | Oil | 2.26 ± 0.8 |
| Tween 80 | Surfactant | 161.46 ± 2.54 |
| Cremophor EL | Surfactant | 27.19 ± 1.15 |
| Cremophor RH 40 | Surfactant | 13.15 ± 1.2 |
| Span 20 | Surfactant | 1.49 ± 0.73 |
| Lauroglycol 90 | Surfactant | 1.34 ± 0.74 |
| PEG 400 | Cosurfactant | 357.14 ± 2.94 |
| Propylene glycol | Cosurfactant | 53.60 ± 1.05 |
| Transcutol P | Cosurfactant | 288.72 ± 2.56 |