Figure 7.

Agonist activity of Compound D12. (A) For dose-dependency of D12, quantitative reverse transcription-polymerase chain reaction (RT-PCR) for AHR target gene CYP1A1 (Cytochrome p450 1A1) is shown at various [D12] following exposure for 12 h. GAPDH expression was used a control. Experiments were run in triplicate. (B) The docking orientation of D12 into the agonist-optimized homology model is shown with the ligand displayed as sticks and colored by atom type as in Figure 2 but with the ligand carbons colored dark green and halogen colored cyan.