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A, Predicted dimerization of TSHR-289 in which the 3BD10 epitope (depicted schematically by the dashed circle) is accessible. However, the M22 binding site is sterically hindered. This favored multimer is consistent with the experimental data for the inactive form of TSHR-289. The region of contact is largely at midzone of the concave surface of TSHR-289. B, Rotation of molecules by 90°.
