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. 2014 Nov 24;111(51):18285–18290. doi: 10.1073/pnas.1419581111

Fig. 1.

Fig. 1.

Pedigree of family ET-1 segregating essential tremor, with genotypes at HTRA2 p.G399S. Individuals with essential tremor (ET) are shown with black symbols, and those with Parkinson disease (PD) with red symbols. Age at onset of tremor for affected individuals, current ages, and genotypes at HTRA2 p.G399S are indicated in this order under the symbols. N indicates the wild-type allele, glycine; V indicates the variant allele, serine, at HTRA2 p.G399S. Individuals who underwent exome sequencing (IV:3, IV:4, VI:5) are indicated with arrows. Subject VI:1, who is unaffected and heterozygous for HTRA2 p.G399S, is presently 37 y old, younger than the mean age at onset of essential tremor among heterozygotes in the family. Phenotypes of four relatives are unknown: I:1, I:2, and III:1 are deceased, and V:11 refused clinical examination.