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. 2014 Nov 24;111(51):18285–18290. doi: 10.1073/pnas.1419581111

Fig. 3.

Fig. 3.

Relationship between HTRA2 genotype and age at onset of essential tremor and severity of tremors. V indicates the variant allele serine, and N indicates the wild-type allele glycine at HTRA2 p.G399S. Subjects heterozygous for the variant allele are indicated NV, and those homozygous for the variant allele are indicated VV. (A) Essential tremor age at onset varies significantly by genotype, P < 0.0001. (B) Severity of postural tremor of homozygous and heterozygous subjects differs significantly; analysis of covariance by genotype with age at examination as covariate yields F = 18.68, (2, 17 df), P < 0.0001. (C) Severity of kinetic tremor of homozygous and heterozygous subjects differs significantly; analysis of covariance by genotype with age at examination as covariate yields F = 9.24, (2, 17 df), P = 0.0019. Individuals with NN genotype and +1 postural or kinetic tremor scores did not fulfill the criteria for essential tremor diagnosis.