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. 2014 Dec 8;111(51):18249–18254. doi: 10.1073/pnas.1415120112

Fig. 4.

Fig. 4.

Ordering regions by location change progression. We selected one top-ranking protein from breast and liver: antibodies HPA017887 and HPA004701, respectively. The Euclidean distances between every pair of regions were calculated by using the features and clustered into a binary hierarchical tree. The leaves were ordered to maximize the sum of similarities between adjacent leaves across the tree. The tree was cut at 10 clusters, and leaves contained in each cluster are indicated by color. The region closest to the mean of each cluster is displayed below the tree from left to right. Normal tiles are outlined in blue; cancer tiles are outlined in red.