Table 2.
Tissue | L:P | E:P | L:A | E:A | Pathway |
Breast | + | — | — | — | HTLV I infection |
+ | — | — | — | One carbon pool by folate | |
— | + | — | — | Proteasome | |
— | + | — | — | ErbB signaling | |
Liver | + | — | — | — | Axon guidance |
— | + | — | — | GPI anchor biosynthesis | |
— | + | — | — | Hypertrophic cardiomyopathy | |
— | + | — | — | Dilated cardiomyopathy | |
Prostate | + | — | — | — | Fatty acid elongation |
+ | — | — | — | HIF-1 signaling | |
— | + | — | — | Oxidative phosphorylation | |
— | + | — | — | PPAR signaling | |
— | + | — | — | Viral myocarditis | |
Bladder | + | — | + | — | Hippo signaling |
— | + | — | — | NF-κB signaling | |
— | + | — | — | p53 signaling | |
— | + | — | — | Transcription misregulation in cancer | |
— | + | — | — | Apoptosis | |
— | + | — | — | Cell cycle | |
— | + | — | — | mRNA surveillance | |
— | + | — | — | Ribosome biogenesis |
Pathway P values were calculated by using individual protein location (L) or expression (E) P values from the pipeline (L:P, E:P) and using P values from pathologist annotations (L:A, E:A). Plus symbol indicates pathway P < 0.01. Values for all pathways are in Dataset S3.