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. 2014 Nov 24;111(51):18309–18314. doi: 10.1073/pnas.1412172111

Fig. 6.

Fig. 6.

Endothelial ELAVL1 regulates postnatal pathological angiogenesis. (A) LLC tumor isograft model in WT and Elavl1 ECKO mice. Representative images of CD31 immunostaining of LLC tumors. Quantitative analysis of vascular density (CD31 positive pixels per field, 20×). LLC tumor volume and LLC tumor weight of WT (0.525 ± 0.056 n = 34) and Elavl1 ECKO mice (0.285 ± 0.031, n = 32). *P < 0.05, **P < 0.005, ***P < 0.0001. (B) PyMT-induced mammary tumor model in WT and Elavl1 ECKO mice. Representative images of CD31 immunostaining of mammary tumors. Total mammary mass of PyMT:WT (3.311 ± 0.202, n = 26) and PyMT: Elavl1 ECKO mice (2.082 ± 0.219, n = 23) at the age of 16 wk. ***P < 0.0001. (Scale bar, 50 µm.)