Table 1.

Fitting results of native states by single- (Eq. 1) and double-exponential (Eqs. 2 and 3) kinetics

	Fitting results
	Two-state model			Three-state model							Experimental data§
Name	$C_0$	λ0*, $\times {10}^{-3}$ ns−1	χ2†, $\times {10}^{-2}$	$C_1$	$m_1$	$C_2$	$m_2$	λ1 (sim)‡, ${\text{ns}}^{-1}$	λ2 (sim)‡, ${\text{ns}}^{-1}$	χ2†, $\times {10}^{-2}$	λ1 (exp)¶, ${\mu \text{s}}^{-1}$	λ2 (exp)¶, ${\mu \text{s}}^{-1}$
Wild type	0.67	0.43	2.4	0.72	0.11	0.15	0.57	0.085	0.00032	1.4	0.030(1)#	<0.0011
Y11R	0.80	3.0	1.8	0.80	0.12	0.10	1.97	0.040	0.0026	1.3	0.025(4)	<0.0014
Y19L	0.018	6.2	0.23	0.019	0.79	0.57	0.35	0.24	0.00041	0.65	0.035(2)	<0.0021
W30F	0.16	1.3	0.84	0.31	0.26	0.68	0.33	0.36	0.00012	1.8	0.054(2)	—
ΔNY11R	0.37	2.8	2.2	0.37	0.05	0.24	0.81	0.76	0.0025	2.0	0.026(3)	<0.0016
ΔNΔCY11R	0.33	3.2	1.8	0.33	0.17	0.37	0.51	0.061	0.0025	1.7	0.050(2)	—
ΔNΔCY11R/L26A	0.46	2.2	2.0	0.47	0.14	0.29	0.55	0.039	0.0019	1.7	0.044(1)	<0.0020

^*λ₀ of Eq. 1.

^†Sum of squares of SI Appendix, Eq. S24, divided by the number of degrees of freedom.

^‡λ₁ (sim) and λ₂ (sim) of Eqs. 2 and 3.

^§Ref. 15.

^¶λ₁ (exp) and λ₂ (exp) are the same as k₁ and k₂ in ref. 15.

^#SDs are in parentheses.