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. 2014 Dec 8;111(51):E5574–E5583. doi: 10.1073/pnas.1414162111

Fig. 3.

Fig. 3.

LiGluR-MAG0460 in RGCs and ON-BCs of rd1 mouse retina drives light responses with similar characteristics (other than for A and B, light intensity for all recordings is 24.7 mW/cm2 or 5.6 × 1016 photons per cm−2⋅s−1). (A–H) MEA recordings of rd1 mouse retinas treated with LiGluR-MAG0460 in RGCs (Left) or ON-BCs (Right). .(A and B) Dynamic range with 3-s stimulation (A: n = 4 retinas, 287 cells; B: n = 4 retinas, 150 cells). Data are mean ± SD. (C and D) Responses to brief (35-ms) flashes of light. (Insets) Responses of single cells in gray (C, n = 47 cells; D, n = 33 cells) and population average in black with mean τoff. All traces were fit exponentially, and the time constants for the peak decay reflecting MAG0460 dark relaxation are shown as scatter plots and summarized in a box plot. (E–H) LiGluR responses to frequency-modulated stimulation (50-ms flashes) (E, n = 77 cells; F, n = 67 cells; G, n = 70 cells; H, n = 65 cells). (Top) Raster plots showing indication of light flashes in blue and single-unit spikes in black (500-ms bins). (Bottom) PSTHs showing population averages of all single-cell responses to 4 Hz and 10 Hz of stimulation in black, with a gray shadow indicating the standard error (SEM).