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TP53 and PI3K/mTOR pathways are significantly mutated in osteosarcoma. GSEA combined with mutational analysis (MutSig2.0) identified 32 significantly mutated pathways (MSigDB Canonical Pathway gene sets) across 59 human osteosarcoma WES samples (q < 0.1). (A) Twenty-two pathways included the TP53 gene and (B) eight pathways implicated the PI3K/mTOR pathway by inclusion of PIK3CA and/or MTOR, while excluding TP53.
