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. Author manuscript; available in PMC: 2014 Dec 31.
Published in final edited form as: Am J Transplant. 2014 May 19;14(6):1249–1258. doi: 10.1111/ajt.12725

Figure 2. Modulation of AMPK and mTOR pathways by CMV.

Figure 2

The AMPK and mTOR pathways with viral effectors are shown. Extracellular signals and upstream proteins resulting in the activation of Akt are shown in greater details in Figure 1. Viral proteins that modulate or interact with these pathways at various stages are shown in green. Compounds or antibodies that were reported to inhibit CMV replication by targeting specific steps in a given pathway are shown in red. Cellular proteins appear in gray. AMPK, AMP-activated protein kinase; CMV, cytomegalovirus; mTOR, mammalian target of rapamycin.