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. Author manuscript; available in PMC: 2014 Dec 31.
Published in final edited form as: Am J Transplant. 2014 May 19;14(6):1249–1258. doi: 10.1111/ajt.12725

Figure 3. Modulation of UPR and proteasome-mediated degradation by CMV.

Figure 3

Simplified schematic of the crosstalk between UPR and proteasome-mediated protein degradation is shown. “S” represents substrate proteins being targeted to the 26S proteasome. Viral proteins that modulate or interact with these pathways at various stages are shown in green. Compounds or antibodies that were reported to inhibit CMV replication by targeting specific steps in a given pathway are shown in red. Cellular proteins appear in gray. CMV, cytomegalovirus; UPR, unfolded protein response.