Table 1.

Cell-signaling pathways controlled by cytomegalovirus

Primary pathway	Virus-derived facilitator (s)	Drug	Reference
AMPK	Unknown	Compound C, AICAR, ST0–609	(4,5)
mTOR	IE72, IE86, UL38	Sirolimus, everolimus, rapamycin, torin	(9–12)
CDKs	Unknown	Roscovitine	(21)
PDGFR-α	gB (?)	Imatinib mesylate, IMC-3G3,	(2)
PI3K	gB	LY294002	(23)
NF-κB	gB/gH, UL76, UL144, IE86	BAY-11–7082, dexamethasone, lactacystin	(25–28,35,36)
RAS/RAF/MEK1/2	IE86, IE72	Sorafenib, U0126, PD98059, FHPI	(38–41)
UPR/proteasome degradation	US2, US11, pp71, UL38	Clotrimazole	(51)
WNT	Unknown	Monensin, nigericin, salinomycin	(56)

AMPK, AMP-activated protein kinase; CDKs, cyclin-dependent kinases; mTOR, mammalian target of rapamycin; NF-κB, nuclear factor kappa beta; PDGFR-α, platelet-derived growth factor receptor-α; PI3K, phosphatidylinositol-3-kinase; UPR, unfolded protein response.