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. 2014 Nov 28;10:74. doi: 10.1186/1744-8069-10-74

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© Langeslag et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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I _CAPS sensitization by depends on S1P ₁ receptor signaling. A, The enhancement of I_CAPS by the S1P₁ specific receptor agonist SEW2871 (1.0 μM) was completely inhibited by pertussis toxin (PTX, 100 ng/ml). The dashed line signifies the zero current. B, Moreover, inhibition of the PI₃K by Wortmannin (WM, 1.0 μM) and PKC (BIM-1, 1.0 μM) fully prevented the potentiation of I_CAPS that was induced by S1P₁ receptor activation by SEW2781 (SEW). *p < 0.05, MWU-test, numbers within the bars represent the number of individual cells recorded.