. Author manuscript; available in PMC: 2015 May 1.

Published in final edited form as: Semin Oncol Nurs. 2014 May;30(2):109–116. doi: 10.1016/j.soncn.2014.03.004

TABLE 1.

The Most-Common Types of Adaptive Settings in Modern Clinical Trials

Stopping early (or late, that is, extending accrual) with a conclusion of either superiority or futility

Adaptively assigning doses to more-efficiently assess the dose-outcome relationship

Dropping arms or doses

Seamless phases of drug development within a single trial

Changing the proportion of patients randomized to each arm

Adaptively homing in on an indication or responder population

Adding arms or doses

Changing accrual rate