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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Nat Commun. 2014 Nov 18;5:5366. doi: 10.1038/ncomms6366

Figure 1. The aging methylome in 1,264 monocyte samples.

Figure 1

The analysis of age and methylation in 1,264 CD14+ monocyte samples included 448,523 CpG sites, of which 37,911 had methylation associated with age (age-dMS; 26,159 negatively associated, 11,752 positively associated, FDR<0.001). The most significant age-dMS (red circle, cg16867657, prho = 0.66, FDR = 3.65×10−140) was detected on chromosome 6 in the ELOVL2 (ELOVL fatty acid elongase 2) promoter. The partial correlation between CpG methylation and age is shown on y-axis, compared to CpG genomic location (by chromosome, x-axis). Linear regression analysis also included the following covariates: race, sex, site of data collection, microarray chip, and residual sample contamination with non-targeted cells (see Methods).