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Time courses of injury and plasma ASS in APAP overdose patients. Plasma samples were collected daily from acetaminophen (APAP) overdose patients with abnormal liver test results. (A-E) Time courses of plasma alanine aminotransferase (ALT) and argininosuccinate synthetase (ASS) from individual APAP overdose patients. (F) Average ASS and ALT levels over time, oriented around the day of peak ALT. Data in (F) are expressed as mean ± SEM for n = 13.
