Figure 4.

Place cells of MPEP-treated animals exhibited remapping 24 h after exploration in the novel environment. (a) Firing rate maps of three cells through all trials in the familiar environment. Recordings were conducted in a square box. All cells showed stable firing patterns through all trials in the familiar environment (b). Firing rate maps of three cells through all trials in the novel environment. Recordings were conducted in a circular box. Cells showed stable firing patterns in two trials on the first day, but remapped on the second day. The remapping firing patterns were preserved and repeatable after a following recording trial on the second day. (c) Spike waveforms of corresponding cells recorded by tetrodes in a time window of 2 msec are shown.