Table 1.

Pharmacokinetic parameters of imepitoin

Effect	Tmax [h]	Terminal T½ [h]	Cmax [ng/mL]	AUCinf [h·ng/mL]	Vz/f [mL/kg]	Cl/f [mL·h/kg]
Fasted	2.17	1.47	17 168	90 301	663	320
Fed	2.02	1.95*	14 892	69 238*	1129*	417*
Females	1.89	1.72	18 055	82 868	833	350
Males	2.30	1.70	14 160*	75 456	899	380
Day 0	2.44	1.75	17 190	101 407	704	285
Day 5	1.75*	1.66	14 873	61 661*	1062*	468*
Females, fasted	2.17	1.47	18 420	92 374	646	311
Females, fed	1.60	1.97	17 698	74 347	1074	395
Males, fasted	2.17	1.48	16 003	88 300	680	329
Males, fed	2.44	1.92	12 532	64 486	1187	440
Day 0, fasted	2.27	1.55	19 756	115 740	556	249
Day 0, fed	2.60	1.96	14 958	88 850	892	325
Day 5, fasted	2.06	1.39	14 921	70 467	789	410
Day 5, fed	1.44	1.94	14 825	53 960	1430	535

Statistical summary of pharmacokinetic parameters obtained from the pharmacokinetic study dosing imepitoin at a nominal dose of 30 mg/kg to six male and female dogs single dose and multiple doses for 4 days under fed and fasting conditions, using a crossover design. Paired comparisons of geometric mean pharmacokinetic parameter were tested for significant difference using t-test. Significantly, different pairs are displayed in bold face. In cases where one parameter was compared (fasted–fed, males–females, day 0–day 5), data are obtained from 12 dogs. In cases where two parameters were compared, data obtained from six dogs were obtained. For two parameter comparison, no statistically significant difference could be obtained.

^*Pairs of mean in bold differ significantly (P < 0.03).