Table 2.
Pharmacokinetic parameters of imepitoin dosed to six beagle dogs at ascending doses of 10–100 mg/kg
Dose [mg/kg] | Cmax [ng/mL] | Tmax [h] | AUCzero [ng·h/mL] | Tlag obs [h] |
---|---|---|---|---|
10 | 1815 ± 920 | 8.67 ± 3.1 | 14 035 ± 8566 | 3.67 ± 0.92 |
20 | 3502 ± 1073 | 10.7 ± 4.0 | 33 551 ± 15 410 | 5.67 ± 0.95 |
50 | 6407 ± 1752 | 18.0 ± 3.8 | 73 081 ± 21 441 | 4.17 ± 1.05 |
100 | 13 554 ± 3333 | 8.67 ± 3.1 | 154 269 ± 49 882 | 2.25 ± 0.94 |
Pharmacokinetic parameters of imepitoin dosed to six beagle dogs (three male and three female dogs) single dose as micronized powder filled in enteric-coated gelatin capsules in an ascending dose design with at least 14 days washout between doses. Displayed is mean ± SEM of six animals.