Table 3.
Excretion balance after oral and intravenous dosing
| Time interval [h] | Urine + Cage wash | Feces | Total |
|---|---|---|---|
| Fraction excreted in males mean [% of oral dose] (CV [%]) | |||
| 0–8* | 0.58 (n < 3) | (no feces) | 0.58 (n < 3) |
| 0–24 | 16.70 (20.9) | 34.41 (92.2) | 51.11 (66.2) |
| 0–48 | 21.86 (20.5) | 75.65 (12.3) | 97.51 (6.4) |
| 0–264 | 26.74 (27.6) | 78.01 (10.8) | 104.74 (2.8) |
| Fraction excreted in females mean [% of oral dose] (CV [%]) | |||
| 0–8* | 7.95 (n < 3) | 0.09 (n < 3) | 8.04 (n < 3) |
| 0–24* | 22.96 (n < 3) | 40.62 (n < 3) | 63.58 (n < 3) |
| 0–48 | 30.88 (23.3) | 45.64 (22.0) | 76.52 (20.8) |
| 0–264 | 38.20 (25.4) | 55.64 (8.4) | 93.84 (8.4) |
| Fraction excreted in females mean [% of intravenous dose] (CV [%]) | |||
| 0–8* | 30.62 (n < 3) | (no feces) | 30.62 (n < 3) |
| 0–24* | 37.58 (19.1) | 54.74 (n < 3) | 74.07 (33.4) |
| 0–48* | 39.87 (19.9) | 68.33 (n < 3) | 85.43 (37.2) |
| 0–264 | 41.52 (21.8) | 62.91 (21.3) | 104.43 (4.4) |
| [14C]Absorptionurine [mean%] (CV [%]: 91.92 (15.5) | |||
Excretion of [14C] imepitoin in three male and three female dogs after oral dosing of 20 mg/kg filled in gelatin capsules, 0.792 MBq/kg, and i.v. dosing of 1 mg/kg dissolved in 70% DMSO in saline, 0.792 MBq/kg, to three female dogs. Displayed are cumulative excretion data in% excretion of total administered dose, given as mean and coefficient of variance (CV). In some intervals, samples were not obtained from all three dogs, and therefore, no CV could be calculated (indicated by *).
The total enteral [14C] absorption in% of administered dose was approximated from comparison of renally excreted fractions of the administered [14C] dose following oral and intravenous administration in female dogs in crossover design.