Table 5.

In vivo protein binding in dogs

Time after dosing [h]	In vivo protein binding (%) mean, ± SEM
	Male, 20 mg/kg p.o.	Female, 20 mg/kg p.o.	Female, 1 mg/kg i.v.
2	60 (n < 3)	69 (n < 3)	59 ± 0.69
4	63 ± 1.62	66 ± 0.69	66 ± 2.66
8	67 ± 2.71	62 ± 7.68	72 ± 1.33

In vivo protein binding of [¹⁴C] imepitoin in three male and three female dogs after oral dosing of 20 mg/kg filled in gelatin capsules, 0.792 MBq/kg, and i.v. dosing of 1 mg/kg dissolved in 70% DMSO in saline, 0.792 MBq/kg, to three female dogs. Displayed is mean ± SEM of three dogs at different time points after dosing. For the 2-h time point after oral dosing, insufficient plasma was obtained for two of three dogs. Protein binding was determined by ultracentrifugation.