Table 7.
Total cytochrome P450 content
| Treatment group | Total cytochrome P450 [nmol/mg protein] | |
|---|---|---|
| Female rats median (range) | Male rats median (range) | |
| Oral vehicle | 0.751 (0.602–1.156) | 1.089 (0.994–1.191) |
| Imepitoin 3 mg/kg p.o. | 0.838 (0.604–1.037) | 1.053 (0.837–1.231) |
| Imepitoin 10 mg/kg p.o. | 0.756 (0.659–0.941) | 1.142 (1.016–1.282) |
| Imepitoin 30 mg/kg p.o. | 0.852 (0.768–0.864) | 1.165 (0.759–1.306) |
| Imepitoin 100 mg/kg p.o. | 0.870 (0.687–1.453) | 1.218 (1.065–1.262) |
| Phenobarbital 40 mg/kg p.o. | 1.492 (1.182–1.802) | 1.886 (1.451–2.321) |
| Corn oil (i.p. vehicle) | 0.808 (0.732–0.902) | 0.874 (0.787–1.087) |
| β-naphthoflavone 40 mg/kg i.p. | 1.389 (1.388–1.389) | 2.136 (1.989–2.283) |
| Dexamethasone 20 mg/kg i.p. | 0.953 (0.903–1.002) | 0.953 (0.899–1.007) |
Microsomal content of total cytochrome P450 enzyme from male and female rats treated with imepitoin, phenobarbital, β-naphthoflavone, or dexamethasone for 7 days. Given are median and range for n = 4 rats per sex and treatment group. For the three positive control groups, the group size was only two males and two females per group.