Table I.
Changes in metabolites observed in plasma obtained from the three groups and the correlation coefficients.
| Metabolite | Chemical shift in ppm (multiplicity) | Assignment | Abnormal Savda syndrome/Healthy (r) | Non-abnormal Savda syndrome/Healthy (r) | Abnormal Savda syndrome/Non-abnormal Savda syndrome (r) |
|---|---|---|---|---|---|
| Lipid (VLDL) | 0.85 (m) | CH3(CH2)n | 0.81 | 0.72 | 0.66 |
| 0.88 (m) | CH3CH2CH2C | ||||
| Isoleucine | 0.93 (t) | δ-CH3 | 0.80 | 0.68 | |
| 1.00 (d) | β-CH3 | ||||
| 1.96 (m) | β-CH | ||||
| Leucine | 0.95 (d) | δ-CH3 | 0.73 | 0.70 | 0.56 |
| 0.97 (d) | δ-CH3 | ||||
| 1.72 (m) | β-CH2/γ-CH | ||||
| 3.65 (dd) | α-CH | ||||
| Valine | 0.98 (d) | CH3 | 0.77 | 0.71 | 0.63 |
| 1.03 (d) | CH3 | ||||
| 2.26 (d) | β-CH2 | ||||
| 3.60 (d) | α-CH2 | ||||
| Lactate | 1.33 (d) | CH3 | 0.68 | −0.48 | |
| 4.11 (q) | CH | ||||
| Alanine | 1.47 (d) | CH3 | 0.71 | 0.69 | |
| 3.76 (q) | α-CH | ||||
| Glycoprotein | 2.03 (s) | NHCO-CH3 | 0.74 | 0.69 | −0.49 |
| Glutamate | 2.13 (m) | half β-CH2 | 0.84 | 0.85 | 0.65 |
| 2.36 (m) | half γ-CH2 | ||||
| 3.75 (t) | α-CH | ||||
| Carnitine | 2.22 (s) | CH3 | −0.65 | −0.57 | −0.54 |
| Tyrosine | 2.52 (d) | half CH2 | 0.79 | 0.69 | 0.60 |
| 2.67 (d) | half CH2 | ||||
| Phenylalanine | 3.03 (s) | CH3 | 0.78 | 0.61 | |
| 3.93 (s) | CH2 | ||||
| Glutamine | 2.10 (m) | half β-CH2 | 0.75 | 0.56 | 0.51 |
| 2.14 (m) | half γ-CH2 | ||||
| Unsaturated lipid | 5.28 (m) | CHCH2CH2 | 0.78 | 0.76 | 0.36 |
| 5.30 (m) | CH=CHCH2CH=CH | ||||
| Acetone | 2.22 (s) | -CH3 | −0.46 | −0.30 | −0.36 |
| Acetoacetate | 2.27 (s) | -CH3 | −0.39 | −0.31 | −0.33 |
Multiplicity: s, singlet; d, doublet; t, triplet; q, quartet; m, multiplet; dd, doublet of doublets. VLDL, very low-density lipoprotein.