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. 2014 Dec 15;172(1):80–92. doi: 10.1111/bph.12938

Figure 1.

Figure 1

Daily FTY720 treatment results in stable phosphorylated FTY720 (FTY720-P) blood levels. (A) Blood levels of phosphorylated and non-phosphorylated FTY720. (B) Expression levels of Sphk2, Ppap2b and Sgpp1 in liver tissues. (C) Expression levels of Sphk2, Ppap2b and Sgpp1 in CNS tissues after acute demyelination. Note constant expression of the two key FTY720-metabolizing enzymes Sphk2 and Sgpp1, paralleled by increased FTY720 and FTY720-P levels in FTY720-treated animals. **P < 0.01, significantly different from controls.