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Structurally distinct calcimimetics potentiate Ca2+o-mediated receptor activation with different potencies. Ca2+o-mediated IP1 accumulation in the presence of cinacalcet (A), R,R-calcimimetic B (B) and AC-265347 (C), over a range of concentrations (0–10 μM). Data are mean + SEM from at least four independent experiments performed in duplicate.
