. Author manuscript; available in PMC: 2015 Jun 1.

Published in final edited form as: Nat Immunol. 2014 Oct 26;15(12):1134–1142. doi: 10.1038/ni.3028

Table 2.

Functional annotation, and specificity, for each module cluster.

Module Cluster	Specificity	Transcriptional activity upon stimulation	Functionality
C0	Common to TIR and bacterial stimulations	downregulation	Cell differentiation, proliferation, adhesion, and metabolism
C1	Common to TIR and bacterial stimulations		Cell signaling, ubiquitination, cell movement, type I IFN, and inflammation
C2	Poly (I:C) specific		Erythrocytes, hemoglobin, and platelets
C3		up and downregulation	Inflammation, phagocytosis, apoptosis
C4	TIR specific	upregulation	Type I and II IFN, Inflammation, caspases, and apoptosis
C5	Bacterial specific		Cell signaling
C6	Common to TIR and bacterial stimulations		Inflammation