Skip to main content
. Author manuscript; available in PMC: 2014 Dec 31.
Published in final edited form as: J Med Chem. 2013 Sep 27;56(20):8066–8072. doi: 10.1021/jm401129n

Table 1.

Pharmacological Assessment of Compounds

Compound R Ke CB1 (nM) Ki CB1a (nM) Ki CB2a (nM) Selectivity (CB1/CB2)
5 Me 17
6 Et 2.3 3.57 426 119
7 Ph 4 2.55 10649 4176
8 Cyclohexyl 3.3 3.35 835 249
9 n-Bu 4.9 19.47 1046 54
10 Cyclohexylmethyl 2.1 1.93 2360 1223
11 i-Bu 5.4 4.01 89.5 22
12 Cyclopentyl 0.89 1.54 60.2 39
13 3-Methylbutyl 7.4 2.67 215 81
14 Cyclopentylmethyl 2.9 2.02 569 282
15 (Piperidin-1-yl)ethyl 789
16 Me2NCH2 140
17 NH2 2768
18 CF3 1.05 6.1 4501 738
a

Displacement was measured using [3H]CP55940