. Author manuscript; available in PMC: 2014 Dec 31.

Published in final edited form as: J Med Chem. 2013 Sep 27;56(20):8066–8072. doi: 10.1021/jm401129n

Table 2.

In vivo pharmacokinetic evaluation of compound 9^a

Time (hours)	Plasma conc. (ng/mL)	Brain conc. (ng/mL)	Brain/Plasma ratio
1	730	24.3	0.03
2	1750	71.5	0.04
4	1565	103	0.07
8	1965	62.5	0.03
24	438	5.35	0.01

9 was dosed orally at 10 mg/kg in 3 SD rats per time-point