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. 2014 Dec 31;9(12):e116142. doi: 10.1371/journal.pone.0116142

Figure 6. Intratracheal instillation of Ad viruses causes elevated expression of Wnt signaling genes associated with fibrosis.

Figure 6

21 days after administration with PBS, bleomycin, and Ad vectors, mice lungs were harvested and were used to extract total RNA for the measurement of mRNA levels of mouse Lrp6 (A), Wnt2 (B), Wnt2b (C), and Wnt5b (D) by real time qRT-PCR. RPL19 gene was used as internal control for qRT-PCR. n≥5; * and #, p<0.05; **, p<0.01; n.s, no significance. * and ** compare the difference between PBS and other groups. # and n.s. compare the difference between the high dose AD vector group and the bleomycin group.