Table 2.
Summary of the type and extent of hepatic lesions in mice fed the choline- and folate-deficient diet for 12 weeks.
| Strain | Group | Lesion | |||||
|---|---|---|---|---|---|---|---|
| Karyomegaly | Steatosis | Necrosis, hepatocyte | Inflammation | Oval cell hyperplasia | Cytoplasmic alteration | ||
| A/J | Control | 0/5 | 0/5 | 0/5 | 1/5 (0.2 ± 0.5) | 0/5 | 5/5 (1.6 ± 0.6) |
| MCFD diet | 0/5 | 5/5 (1.4 ± 0.6) | 0/5 | 5/5 (1.0 ± 0.0) | 1/5 (0.2 ± 0.5) | 4/5 (1.2 ± 0.8) | |
| C57BL/6J | Control | 0/5 | 0/5 | 1/5 (0.2 ± 0.5) | 1/5 (0.2 ± 0.5) | 0/5 | 2/5 (0.8 ± 1.1) |
| MCFD diet | 0/5 | 5/5 (1.8 ± 0.5) | 0/5 | 5/5 (1.4 ± 0.6) | 3/5 (0.6 ± 0.6) | 3/5 (0.6 ± 0.6) | |
| C3H/HeJ | Control | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
| MCFD diet | 0/5 | 5/5 (2.6 ± 0.6) | 0/5 | 5/5 (1.0 ± 0.0) | 0/5 | 0/5 | |
| 129S1/SvImJ | Control | 0/5 | 0/5 | 0/5 | 1/5 (0.2 ± 0.5) | 0/5 | 5/5 (1.8 ± 0.5) |
| MCFD diet | 0/5 | 5/5 (3.8 ± 0.5) | 0/5 | 5/5 (1.4 ± 0.6) | 1/5 (0.2 ± 0.5) | 0/5 | |
| CAST/EiJ | Control | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 2/5 (0.8 ± 1.1) |
| MCFD diet | 4/4 (1.0 ± 0.0) | 4/4 (3.5 ± 0.6) | 0/4 | 3/4 (0.8 ± 0.5) | 1/4 (0.3 ± 0.5) | 3/4 (1.0 ± 0.8) | |
| PWK/PhJ | Control | 0/5 | 0/5 | 0/5 | 1/5 (0.2 ± 0.5) | 0/5 | 1/5 (0.2 ± 0.5) |
| MCFD diet | 5/5 (1.4 ± 0.6) | 5/5 (3.8 ± 0.5) | 5/5 (1.0 ± 0.0) | 5/5 (2.0 ± 0.0) | 5/5 (1.2 ± 0.5) | 5/5 (4.0 ± 0.0) | |
| WSB/EiJ | Control | 0/5 | 0/5 | 0/5 | 1/5 (0.2 ± 0.5) | 0/5 | 4/5 (1.0 ± 0.7) |
| MCFD diet | 5/5 (2.0 ± 0.0) | 5/5 (4.0 ± 0.0) | 5/5 (3.8 ± 0.5) | 5/5 (3.8 ± 0.5) | 5/5 (3.6 ± 0.6) | 5/5 (2.2 ± 0.5) | |
a
Lesion prevalence.
b
(Mean severity).