. 2014 Dec 4;57(24):10544–10550. doi: 10.1021/jm501527z

Table 3. Modifications of the Acetamide and 4-Oxo-[1]benzopyrano[4,3-c]pyrazole Regions of 8k for CpIMPDH Inhibition.

graphic file with name jm-2014-01527z_0006.jpg

ID	method	R₁	R₂	R₃	X	Y	IC₅₀(nM)
8k	A	H	H	H	O	C=O	20 ± 4
8l	C	Me	H	H	O	C=O	>5000
8m	C	H	Me	H	O	C=O	63 ± 11
8n	C	H	H	Me	O	C=O	2000
13e	D	H	H	H	O	CH₂	70 ± 27
13f	D	H	H	H	CH₂	CH₂	100 ± 30