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. 2014 Dec 12;57(24):10486–10498. doi: 10.1021/jm501541j

Table 3. Stability of Diastereoisomers of 12–18 in Solution in MeOH/H2O with 0.1% TFA.

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    ratio after HPLC C:D:E
entry compound 0 h 1 days 2 days
1 12D 0:100:0 0:100:0 0:100:0
2 13D 0:99:1 0:97:3 0:94:6
3 14D 0:99.4:0.6 0:90:10 0:77:23
4 15C 99.7:0.3:0 96:4:0 93:7:0
5 15D 2:98:0 3:97:0 2:98:0
6 16C+16D 73:27:0 0:100:0 0:100:0
7 16D 0:100:0 0:100:0 0:100:0
8 17C+17D 31:69:0 0:100:0 0:100:0
9 17D 0:100:0 0:100:0 0:100:0
10 18D 0:100:0 0:91:9 0:83:17