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. 2014 Dec 12;57(24):10486–10498. doi: 10.1021/jm501541j

Table 4. Stability of Diastereoisomers 21–29 in MeOH/H2O Solution with 0.1% TFA.

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    ratio after HPLC C:D:E
entry compound 0 h 1 days 2 days
1 21D 0:98:0.3 0:93:5 0:89:9
2 22C 96:4:0 92:8:0 89:11:0
3 22D 0:100:0 0:100:0 0:100:0
4 23C+23D 53:47:0 0:99.3:0.7 0:99.3:0.7
5 23D 0:100:0 0:100:0 0:99.8:0.2
6 24D 0:100:0 0:98:2 0:97:3
7 25C 100:0:0 98:2:0 97:3:0
8 25D 0:100:0 0:100:0 0:100:0
9 26C+26D 35:65:0 0:100:0 0:100:0
10 26D 0:100:0 0:100:0 0:100:0
11 27D 0:100:0 0:98:2 0:96:4
12 28C 99.7:0.3:0 98:2:0 89:11:0
13 28D 0:100:0 0:100:0 0:100:0
14 29C+29D 32:68:0 0:100:0 0:100:0
15 29D 0:100:0 0:100:0 0:100:0