. 2014 Dec 12;57(24):10486–10498. doi: 10.1021/jm501541j

Table 5. Stability Comparison of First-Generation and Second-Generation Spiro-oxindoles.

graphic file with name jm-2014-01541j_0018.jpg

		% composition of compound in 1:1 CH₃CN/H₂O
entry	compound	0 h	1 days	3 days	6 days
1	23D	100	100	99.6	99.2
2	26D	100	100	100	100
3	29D	100	100	100	100
4	MI-63^a	98.09	90.79	86.9	82.7
5	MI-147^a	97.45	95.80	95.7	91.4
6	3 (MI-888)^a	100	99.56	98.6	97.7

Reference (24).