Table 5. Off Target Profiling Results for Compound 19 at 10 μM (>50% Inhibition).
| entry | biological target | Eurofins Panlabs assay codea | species | percent inhibition (%)b |
|---|---|---|---|---|
| 1 | calcium channel, L-type, benzothiazepine | 214510 | rat | 52 |
| 2 | calcium channel, L-type, dihydropyridine | 214600 | rat | 70 |
| 3 | cannabinoid CB1 | 217030 | human | 86 |
| 4 | serotonin (5-hydroxytryptamine) 5-HT2B | 271700 | human | 54 |
| 5 | norepinephrine transporter | 204410 | human | 54 |
a
Detailed assay descriptions can be found at https://www.eurofinspanlabs.com/catalog.
b
A full list of targets and percent inhibition by compound 19 is provided in the Supporting Information.