Table 2. Association between haplotypes of PGC tagSNPs and risks of atrophic gastritis and gastric cancer.
| Haplotypeb | CON | GA | GC | GA vs. CON | GC vs. CON | ||
| OR(95%CI)a | Pa | OR(95%CI) | Pa | ||||
| TTCA | 70(4.18%) | 100(6.76%) | 74(6.00%) | 1.78(1.20,2.65) | 0.001 | 1.70(1.11,2.60) | 0.021 |
| TTCG | 467(27.84%) | 364(24.62%) | 326(26.63%) | 0.86(0.72,1.03) | 0.112 | 0.96(0.80,1.16) | 0.670 |
| TTGG | 65(3.90%) | 45(3.05%) | 27(2.19%) | 0.59(0.37,0.94) | 0.023 | 0.54(0.31,0.94) | 0.017 |
| TCCA | 166(9.88%) | 155(10.47%) | 126(10.27%) | 1.32(1.00,1.73) | 0.053 | 1.17(0.87,1.57) | 0.277 |
| TCCG | 516(30.73%) | 465(31.39%) | 366(29.87%) | 1.02(0.86,1.21) | 0.851 | 0.92(0.75,1.10) | 0.422 |
| TCGA | 134(8.01%) | 106(7.17%) | 101(8.23%) | 0.83(0.62,1.12) | 0.246 | 1.00(0.74,1.35) | 0.896 |
| CTCA | 133(7.90%) | 155(10.47%) | 111(9.06%) | 1.33(1.01,1.74) | 0.041 | 1.19(0.88,1.61) | 0.837 |
| CTCG | 105(6.24%) | 74(5.03%) | 71(5.78%) | 0.78(0.54,1.12) | 0.178 | 0.90(0.62,1.30) | 0.216 |
a
, P, OR and corresponding 95%CI for individual haplotype test compares with the remaining haplotype pooled together;
b
, haplotype of Haplotype of rs6941539 C>T-rs6912200 C>T-rs3789210 C>G-rs6939861 G>A. All tests were adjusted by age, sex and status of H. pylori infection. The results highlighted in bold show associations with disease risk (P values <0.05). Abbreviation: CON: healthy controls; GA: atrophic gastritis, GC: gastric cancer.