Table 6. Correlation between PGC tagSNP and levels of PGC protein expression in serum.
| SNP | Total | Healthy subject | Atrophic gastritis | Gastric cancer | ||||||||||||
| N | Median(25%,75%) | Pa | Pb | N | Median(25%,75%) | Pa | Pb | N | Median(25%,75%) | Pa | Pb | N | Median(25%,75%) | Pa | Pb | |
| rs3789210 | 0.883 | 0.853 | 0.507 | 0.627 | ||||||||||||
| CC | 1421 | 9.30(6.00,16.50) | 629 | 7.70(5.30,11.88) | 584 | 11.70(6.87,19.30) | 208 | 12.65(7.01,21.84) | ||||||||
| CG | 391 | 9.20(6.00,17.00) | 0.871 | 185 | 7.49(5.10,10.15) | 0.364 | 141 | 12.40(6.97,20.50) | 0.564 | 65 | 16.00(8.35,24.29) | 0.119 | ||||
| GG | 38 | 9.70(6.55,17.00) | 0.741 | 18 | 8.85(5.95,16.48) | 0.212 | 12 | 12.10(6.20,17.05) | 0.439 | 8 | 11.98(7.05,23.15) | 0.890 | ||||
| CG/GG | 429 | 9.20(6.07,17.00) | 0.727 | 203 | 7.50(5.10,10.50) | 0.596 | 153 | 12.40(6.80,19.40) | 0.723 | 73 | 14.98(8.17,24.29) | 0.159 | ||||
| rs6912200 | 0.300 | 0.026 | 0.603 | 0.582 | ||||||||||||
| CC | 470 | 10.05(6.10,16.72) | 218 | 8.10(5.38,12.37) | 188 | 12.45(7.51,19.90) | 64 | 10.28(7.33,23.90) | ||||||||
| CT | 931 | 9.20(5.80,16.70) | 0.177 | 416 | 7.68(5.30,11.70) | 0.467 | 368 | 11.40(6.20,18.88) | 0.039 | 147 | 14.50(7.04,23.27) | 0.271 | ||||
| TT | 449 | 9.00(6.20,16.35) | 0.248 | 198 | 7.25(5.09,9.77) | 0.055 | 181 | 11.80(7.75,19.85) | 0.512 | 70 | 13.50(7.23,22.07) | 0.420 | ||||
| CT/TT | 1380 | 9.10(5.90,16.68) | 0.153 | 614 | 7.50(5.20,10.73) | 0.196 | 549 | 11.60(6.60,19.20) | 0.083 | 217 | 14.20(7.07,22.95) | 0.271 | ||||
| rs6939861 | 0.296 | 0.278 | 0.268 | 0.829 | ||||||||||||
| GG | 795 | 9.00(5.90,16.90) | 384 | 7.50(5.32,11.70) | 297 | 12.80(6.95,18.50) | 114 | 14.30(6.38,23.07) | ||||||||
| AG | 888 | 9.30(6.03,16.28) | 0.979 | 383 | 7.70(5.20,11.70) | 0.938 | 361 | 11.00(6.60,18.50) | 0.167 | 144 | 13.33(7.63,23.58) | 0.784 | ||||
| AA | 167 | 10.46(6.70,16.30) | 0.334 | 65 | 8.07(5.60,11.30) | 0.839 | 79 | 13.06(8.10,19.30) | 0.736 | 23 | 12.30(7.04,23.30) | 0.829 | ||||
| AG/AA | 1055 | 9.40(6.10,16.30) | 0.800 | 448 | 7.80(5.20,11.68) | 0.990 | 440 | 11.45(6.70,18.50) | 0.280 | 167 | 13.20(7.60,23.30) | 0.851 | ||||
| rs6941539 | 0.302 | 0.369 | 0.786 | 0.304 | ||||||||||||
| CC | 1327 | 9.30(6.20,16.74) | 604 | 7.70(5.40,11.60) | 514 | 11.85(6.90,19.30) | 209 | 14.40(7.75,23.55) | ||||||||
| CT | 481 | 9.20(5.70,15.89) | 0.147 | 208 | 7.88(5.20,11.88) | 0.828 | 207 | 11.40(6.50,18.36) | 0.541 | 66 | 9.12(5.41,19.18) | 0.007 | ||||
| TT | 42 | 10.35(5.58,18.68) | 0.929 | 20 | 6.00(4.95,10.45) | 0.253 | 16 | 18.35(8.47,23.64) | 0.243 | 6 | 17.80(8.95,29.50) | 0.687 | ||||
| CT/TT | 523 | 9.20(5.70,15.90) | 0.163 | 228 | 7.79(5.19,11.70) | 0.618 | 223 | 11.70(6.70,19.40) | 0.751 | 72 | 10.10(5.53,21.67) | 0.014 | ||||
a
, P values for Mann-Whitney Test comparing the difference of variables between two groups;
b
, P values for partial correlation analysis controlling for sex, age and status of H. pylori infection. The results highlighted in bold show associations with expression levels of PGC protein in serum (P values <0.05).