Table 2. Interaction between gene variants and smoking status, alcohol consumption and BMI on fibrinogen concentration (in g/L) with lowest p value for interaction.

Environmental factor x SNP	Chr	Position	A1*	A2	% A1	Beta (SE)	P value	N studies	Direction**	I2 index
Smoking status x rs10519203	15	76601101	A	G	64.8	−0.048 (0.009)	6.2×10−08	22	---+—+-+-------+-+---	45.4%
Alcohol consumption x rs11102001	1	110011733	A	G	59.0	0.057 (0.012)	7.0×10−07	18	++++-++?+++-+++++?++	0.0%
BMI x rs7120820	11	21350435	T	C	37.6	0.004 (0.009)	1.8×10−06	21	++++-++—+-+-+---++?++	20.2%

BMI: body mass index, SNP: single nucleotide polymorphism, Chr: chromosome, SE: standard error.

* Allele 1 is effect allele, ** The order of studies under “direction” refers to the order of studies in Table 1 .