Table 3. Interaction with smoking status for association with fibrinogen concentration (in g/L) in SNPs with previously reported interactions (Green et al. 1993; Thomas et al. 1996) or among SNPs associated with circulating fibrinogen (Sabater-Leal et al. 2013).
| SNP | Chr | Position | A1* | A2 | % A1 | Beta (SE) | P value | N studies | Direction** | I2 index |
| Significant interaction according to Green et al. (1993) and Thomas et al. (1996): | ||||||||||
| rs1800790 | 4 | 155703158 | A | G | 23.2 | 0.029 (0.011) | 0.0062 | 22 | +++++---++-+++-++—+— | 59.2% |
| Significant SNPs according to Sabater-Leal et al. (2013): | ||||||||||
| rs1938492 | 1 | 65890417 | A | C | 62.1 | 0.017 (0.009) | 0.058 | 22 | ++-+---+-+++-+-+++—++ | 0.0% |
| rs4129267 | 1 | 152692888 | T | C | 39.1 | −0.004 (0.009) | 0.614 | 22 | +-+-+-++—+++++---++-+ | 43.9% |
| rs10157379 | 1 | 245672222 | T | C | 62.3 | 0.008 (0.009) | 0.386 | 21 | ------+++++-++++++-?++ | 0.0% |
| rs12712127 | 2 | 102093093 | A | G | 40.6 | 0.009 (0.009) | 0.286 | 22 | ++-++-++—+-++-+++++— | 0.0% |
| rs6734238 | 2 | 113557501 | A | G | 58.6 | −0.005 (0.009) | 0.561 | 22 | +---+++-+-+-+—+-+-+-+ | 0.8% |
| rs715 | 2 | 211251300 | T | C | 68.0 | −0.007 (0.011) | 0.501 | 17 | -?+?-+—?+—?+-+—+?+- | 0.7% |
| rs1476698 | 2 | 241945122 | A | G | 64.5 | 0.008 (0.009) | 0.357 | 22 | ++------+---+—++++-++ | 34.9% |
| rs1154988 | 3 | 137407881 | A | T | 78.1 | −0.013 (0.010) | 0.194 | 22 | -----+-++++---+—+-+-+ | 0.0% |
| rs16844401 | 4 | 3419450 | A | G | 7.5 | 0.017 (0.020) | 0.392 | 18 | —??+?-+++++—+++-+?-+ | 1.0% |
| rs1800789 | 4 | 155702193 | A | G | 21.1 | 0.031 (0.011) | 0.0028 | 22 | +++++---++-++—++----- | 61.1% |
| rs11242111 | 5 | 131783957 | A | G | 5.7 | 0.051 (0.033) | 0.124 | 9 | +??+?+?+?-?++?-????+?? | 30.0% |
| rs2106854 | 5 | 131797073 | T | C | 20.8 | −0.004 (0.011) | 0.737 | 22 | ---------+-+++++-+++++ | 0.0% |
| rs10226084 | 7 | 17964137 | T | C | 51.9 | −0.008 (0.009) | 0.374 | 22 | -++++---+---+-++---+— | 0.0% |
| rs2286503 | 7 | 22823131 | T | C | 36.1 | −0.013 (0.009) | 0.131 | 22 | +-+-++++++—+-+----+— | 0.0% |
| rs7464572 | 8 | 145093155 | C | G | 59.7 | −0.004 (0.009) | 0.672 | 19 | +?++----?-++?-+----+-+ | 0.0% |
| rs7896783 | 10 | 64832159 | A | G | 48.4 | −0.014 (0.008) | 0.094 | 22 | -+-++—++-----+----+— | 0.0% |
| rs1019670 | 11 | 59697175 | A | T | 35.8 | −0.009 (0.009) | 0.345 | 22 | +---++++++---+----+--- | 0.0% |
| rs7968440 | 12 | 49421008 | A | G | 64.0 | 0.003 (0.009) | 0.855 | 22 | +-+-+----+----++++—++ | 52.0% |
| rs434943 | 14 | 68383812 | A | G | 31.7 | −0.002 (0.010) | 0.884 | 21 | -----+-++++----++++?++ | 0.0% |
| rs12915708 | 15 | 48835894 | C | G | 30.6 | −0.003 (0.009) | 0.776 | 22 | -+—++---+-++----+-+— | 20.7% |
| rs7204230 | 16 | 51749832 | T | C | 69.7 | 0.008 (0.010) | 0.447 | 19 | +?-++—+?+—?-+++++-++ | 0.0% |
| rs10512597 | 17 | 70211428 | T | C | 17.9 | −0.008 (0.012) | 0.490 | 21 | ----+-+—+-+—+-+++?++ | 0.0% |
| rs4817986 | 21 | 39387382 | T | G | 27.9 | −0.025 (0.010) | 0.011 | 20 | —?+---+-----++---+?— | 12.8% |
| rs6010044 | 22 | 49448804 | A | C | 79.5 | 0.005 (0.012) | 0.669 | 21 | +—++++---++++—?-++++ | 0.0% |
SNP: single nucleotide polymorphism, Chr: chromosome, SE: standard error.
* Allele 1 is effect allele, ** The order of studies under “direction” refers to the order of studies in Table 1 .