Table 2. High frequency regions (HFRs) of focal aberrations and gene(s) within or overlapping these HFRs.
HFR1 Focal abberration | Focal2 | Total3 | ||||||
Chrom. | Start (bp) | End (bp) | Size (kb) | Gain | Loss | Gain | Loss | Genes |
1 | 68394382 | 68461186 | 67 | 2 | 0 | 10 | 0 | GPR177 |
1 | 166259174 | 166263398 | 4 | 2 | 0 | 8 | 0 | IQWD1 |
1 | 145961855 | 146262362 | 301 | 2 | 1 | 8 | 1 | FAM108A2, NBPF11 |
2 | 51022554 | 51022614 | 0.06 | 2 | 0 | 3 | 1 | NRXN1 |
2 | 153790092 | 154905667 | 1116 | 2 | 0 | 3 | 1 | RPRM, GALNT13 |
2 | 212844992 | 212863839 | 19 | 1 | 3 | 1 | 5 | ERBB4 |
2 | 237017756 | 237067914 | 50 | 0 | 3 | 1 | 8 | IQCA1 |
3 | 38177003 | 38246945 | 70 | 1 | 2 | 1 | 6 | OXSR1 |
3 | 57426028 | 57504090 | 78 | 0 | 2 | 0 | 8 | DNAH12L |
3 | 59855182 | 59891414 | 36 | 0 | 2 | 0 | 9 | FHIT |
3 | 60208127 | 60420353 | 212 | 0 | 2 | 0 | 9 | FHIT |
3 | 24260772 | 24290280 | 30 | 0 | 3 | 0 | 5 | THRB |
3 | 32341229 | 32364439 | 23 | 0 | 3 | 0 | 6 | CMTM8 |
4 | 90072621 | 90081252 | 9 | 0 | 2 | 1 | 3 | FAM13A1 |
4 | 183476755 | 184028352 | 552 | 0 | 2 | 1 | 7 | ODZ3 |
4 | 73484965 | 73485361 | 0.396 | 0 | 15 | 0 | 17 | ADAMTS3 |
5 | 170214294 | 170645196 | 431 | 1 | 2 | 1 | 5 | RANBP17 |
5 | 55470977 | 55502030 | 31 | 0 | 2 | 1 | 10 | ANKRD55 |
5 | 110611609 | 110683366 | 72 | 0 | 2 | 0 | 8 | CAMK4 |
5 | 135294758 | 135330960 | 36 | 0 | 2 | 0 | 8 | FBXL21, LECT2 |
5 | 158336707 | 158375568 | 39 | 0 | 4 | 0 | 7 | EBF1 |
5 | 58765648 | 58766102 | 0.454 | 0 | 5 | 0 | 12 | PDE4D |
5 | 80023854 | 80024518 | 0.664 | 0 | 11 | 0 | 14 | MSH3 |
6 | 44998738 | 45119343 | 121 | 5 | 0 | 11 | 0 | SUPT3H |
6 | 13965760 | 14255124 | 289 | 2 | 1 | 4 | 1 | CD83, RNF182 |
6 | 14051934 | 14103151 | 51 | 2 | 1 | 4 | 1 | RNF182 |
6 | 86262042 | 86335470 | 73 | 0 | 3 | 0 | 11 | SNX14, NT5E |
6 | 110510873 | 110539046 | 28 | 0 | 4 | 0 | 12 | WASF1 |
7 | 57480106 | 57659360 | 179 | 2 | 0 | 3 | 1 | ZNF716 |
7 | 63149422 | 63486197 | 337 | 2 | 0 | 3 | 1 | ZNF679, ZNF735 |
7 | 943615 | 954205 | 11 | 1 | 2 | 1 | 3 | ADAP1 |
7 | 15536047 | 15536441 | 0.394 | 0 | 6 | 0 | 7 | TMEM195 |
8 | 128437695 | 130578879 | 2141 | 4 | 1 | 14 | 1 | TMEM75, MYC, POU5F1P1 |
8 | 124855221 | 124894704 | 39 | 3 | 0 | 17 | 0 | FAM91A1 |
8 | 132030642 | 132421393 | 391 | 2 | 0 | 16 | 0 | ADCY8 |
8 | 64257961 | 64390486 | 133 | 2 | 1 | 12 | 1 | YTHDF3 |
8 | 145064850 | 145118710 | 54 | 2 | 1 | 11 | 1 | PLEC1 |
8 | 25130171 | 25130291 | 0.12 | 1 | 14 | 1 | 15 | DOCK5 |
9 | 3339487 | 3417226 | 78 | 1 | 2 | 1 | 8 | RFX3 |
9 | 71289871 | 71308842 | 19 | 0 | 2 | 0 | 5 | APBA1 |
9 | 87357661 | 87432833 | 75 | 0 | 3 | 0 | 5 | AGTPBP1 |
9 | 33230225 | 33242111 | 12 | 0 | 8 | 0 | 12 | SPINK4 |
10 | 115580402 | 115675237 | 95 | 1 | 2 | 1 | 11 | NHLRC2, DCLRE1A |
10 | 25604754 | 25659341 | 55 | 1 | 3 | 1 | 15 | GPR158 |
10 | 15898437 | 15929438 | 31 | 0 | 2 | 0 | 16 | C10orf97 |
10 | 38082301 | 38147982 | 66 | 0 | 2 | 1 | 11 | ZNF248 |
10 | 71648150 | 71656573 | 8 | 0 | 2 | 0 | 12 | PPA1 |
10 | 123566469 | 123752493 | 186 | 0 | 2 | 1 | 13 | TACC2, NSMCE4A, ATE1 |
10 | 89716166 | 89756083 | 40 | 0 | 3 | 0 | 14 | PTEN |
10 | 72166137 | 72172267 | 6 | 0 | 4 | 0 | 12 | ADAMTS14 |
11 | 20922810 | 20971401 | 49 | 0 | 2 | 0 | 3 | NELL1 |
11 | 92517181 | 92571937 | 55 | 0 | 2 | 0 | 5 | SLC36A4 |
11 | 104441220 | 104484303 | 43 | 0 | 2 | 0 | 4 | CARD17 |
11 | 47391562 | 47453463 | 62 | 0 | 3 | 0 | 3 | CUGBP1, RAPSN, PSMC3, SLC39A13 |
11 | 102486510 | 102663548 | 177 | 0 | 4 | 0 | 5 | DYNC2H1 |
12 | 51710169 | 51719305 | 9 | 0 | 2 | 0 | 5 | EIF4B |
12 | 91645948 | 91679726 | 34 | 0 | 2 | 1 | 5 | PLEKHG7 |
12 | 18413696 | 18414167 | 0.471 | 0 | 4 | 1 | 7 | PIK3C2G |
13 | 92502207 | 93946439 | 1444 | 1 | 2 | 1 | 12 | DCT, GPC6 |
13 | 34399863 | 34517051 | 117 | 0 | 5 | 0 | 14 | NBEA |
14 | 59138607 | 59161895 | 23 | 2 | 1 | 5 | 1 | RTN1 |
14 | 69961223 | 69998909 | 38 | 0 | 6 | 0 | 6 | ADAM21, ADAM21P |
15 | 59943982 | 60046989 | 103 | 0 | 2 | 1 | 3 | VPS13C |
16 | 87557619 | 87557679 | 0.06 | 1 | 2 | 1 | 8 | CBFA2T3 |
16 | 87527215 | 87549395 | 22 | 1 | 3 | 1 | 9 | CBFA2T3 |
16 | 71734726 | 71798103 | 63 | 0 | 2 | 0 | 6 | C16orf47 |
16 | 45728834 | 45887805 | 159 | 0 | 4 | 0 | 6 | ITFG1, NETO2 |
17 | 37018570 | 37057586 | 39 | 0 | 4 | 1 | 7 | KRT42P, KRT17, KRT16 |
19 | 33996261 | 34984966 | 989 | 4 | 1 | 12 | 1 | C19orf12, PLEKHF1, POP4, VSTM2B, UQCRFS1, UQCRFSL1 |
19 | 532070 | 556653 | 25 | 0 | 4 | 1 | 4 | HCN2, BSG |
19 | 60711906 | 60737394 | 25 | 0 | 4 | 1 | 6 | SBK2 |
X | 33147645 | 33243866 | 96 | 1 | 6 | 1 | 15 | DMD |
HFR: common region of focal aberration (gain or loss);
Focal: number of samples with focal aberration;
Total: total number of samples containing the HFR of the focal aberration. Genes in bold have been reported in the Cancer Gene Census list.