Table 1. The highly kidney-enriched genes according to the transcriptome profiling.
Gene name | Description | Main localisation | Kidney mRNA | TS score | HPA |
UMOD | Uromodulin | Membrane | 1421 | 647 | Yes |
SLC22A8 | Solute carrier family 22, member 8 | Membrane | 269 | 633 | Yes |
SLC12A1 | Solute carrier family 12, member 1 | Membrane | 406 | 460 | Yes |
TMEM174 | Transmembrane protein 174 | Membrane | 97 | 443 | Yes |
MCCD1 | Mitochondrial coiled-coil domain 1 | Membrane | 27 | 271 | Yes |
SLC34A1 | Solute carrier family 34, member 1 | Membrane | 176 | 219 | Yes |
AQP2 | Aquaporin 2 (collecting duct) | Membrane | 315 | 177 | Yes |
SLC22A12 | Solute carrier family 22, member 12 | Membrane | 108 | 162 | Yes |
SLC22A2 | Solute carrier family 22, member 2 | Membrane | 97 | 154 | Yes |
SLC22A6 | Solute carrier family 22, member 6 | Membrane | 198 | 144 | No |
KCNJ1 | Potassium inwardly-rectifying channel | Membrane | 132 | 140 | Yes |
SLC7A13 | Solute carrier family 7, membrane 13 | Membrane | 19 | 118 | No |
NPHS2 | Nephrosis 2, idiopathic, (podocin) | Membrane | 68 | 116 | Yes |
SLC6A18 | Solute carrier family 6, member 18 | Membrane | 11 | 106 | Yes |
SLC36A2 | Solute carrier family 36, member 2 | Membrane | 64 | 97 | Yes |
SLC12A3 | Solute carrier family 12, member 3 | Membrane | 129 | 84 | Yes |
SLC22A13 | Solute carrier family 22, member 13 | Membrane | 12 | 74 | Yes |
ATP6V1G3 | ATPase, H+ transporting, lysosomal | Membrane | 38 | 73 | Yes |
MIOX | Myo-inositol oxygenase | Cytoplasm | 625 | 73 | Yes |
TMEM207 | Transmembrane protein 207 | Membrane | 10 | 59 | Yes |
‘Kidney mRNA’ shows the average FPKM value in the kidney samples, ‘TS’ shows the tissue specificity score and ‘HPA’ shows if there was corresponding data in the Human Protein Atlas. Individual FPKM values and variance in the four different kidney samples are found in S3 File.