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. 2014 Dec 31;9(12):e115869. doi: 10.1371/journal.pone.0115869

Table 2. Demographic data of patients with ototoxicity included for meta-analysis.

Cases/Total Ethnicity Age (y) Types of cancer Gender of cases Cumulative dose Cranial irradiation Otoprotectant Vincristine Aminoglycocide
N Median Male % Median (mg/m2) % used antibiotics
Ross et al.6 106/162 Mixed population 6 Different cancers 67.0% 400 mg/m2 18.50% No information Yes Yes
Pussegoda et al.7 87/155 Mixed population 6 Different cancers 49.4% 400 mg/m2 18% No information Yes Yes
Yang et al., radiation cohort8 131/195 Mixed population 7 Medulloblastoma 68.8%* 300 mg/m2* 100%* Yes Yes No information
Yang et al., no radiation8 35/38 Mixed population 8 Medulloblastoma 65.0% 500 mg/m2 0 Yes Yes No information
Hagleitner, this study 22/80 Dutch ancestry 15 Osteosarcoma 40.0% 500 mg/m2 0 No Yes No
Patino-Garcia, this study 18/34 European ancestry 12 Osteosarcoma 55.3% 500 mg/m2 0 No Yes Yes
*data of total group as published by Yang et al.