Figure 2. Results of the primary outcome measurements of gait.

Mean supported stepping score (a), regulatory index (b) and OFS (c) during weeks 1–2, 5–6 and 9–10 did not change significantly (see p values for ß ^k ₁ provided in Table 4), showing that there is no significant treatment effect carried over from the treatment periods. Mean supported stepping score (d), regulatory index (e) and OFS (f) for 4-AP and t-butyl treatment periods compared to the preceding 2 week period. Stepping score and OFS show significant improvement with treatment (***) (see p values for ß ^k ₀ provided in Table 4); Data represents mean ± SD, CTR: the 2-week control period immediately preceding treatment.