Extended Data Figure 9. Behavioral tests in Cntnap4 mice.

a,b No major changes in anxiety levels were observed in the mutant mice as indicated by time and distance spent in periphery versus center in Open Field Arena (OFA) (n = 14 WT, n = 13 HET, n = 10 KO). c, No major changes observed in extent of marble burying in the mutant versus control mice (n = 17 WT, n = 33 HET, n = 14 KO). d–f, No difference was found in the time spent in the open or closed arms, total distance traveled or center crossings in the Elevated Plus Maze (EPM) between mutants and control animals (n = 14 WT, n = 12 HET, n = 11 KO). g, Grooming tracks with the Cntnap4 mutant allele. A series of representative images of Cntnap4 mutant mice (Het and KO) cross-fostered by Swiss Webster wild type (SW WT) dam or SW WT mice cross-fostered onto Cntnap4 mutant dam. Grooming status documented at two different ages: just after weaning (P22) and at P76. At P22, presence or absence of allo-grooming by the mother is apparent, whereas at P76 the presence or lack of whiskers depends on the mouse’s genotype. See Supplementary Results for more detail.