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. 2015 Jan;100(1):e14–e17. doi: 10.3324/haematol.2014.112193

Figure 2.

Figure 2.

PAX5/CHFR fusion transcript and novel CHFR RNA isoform. (A) Partial genomic organization of CHFR on chromosome 12, and sequence of the newly identified exons (in bold), according to GRCh37/hasg19. Splicing donor/acceptor sites are indicated as underlined. (B) Schematic representation of CH-001 and the novel CH-029 CHFR transcript isoforms. In addition, a schematic representation of wild-type PAX5 and of the two alternative PAX5/CHFR fusion transcripts is reported. (C) PAX5-CH-029 transcript 1 (upper right panel) and transcript 2 (lower right panel) are exclusively expressed in Patient 5 (lane 1) and not in control BCP-ALL cell lines (TOM1, lane 3; REH, lane 4). Lane 2: no template control.