Fig. 1. Domain structure and PTMs of PPARγ. The PPARγ2 protein contains an additional 30 amino acids at the N-terminus, compared with PPARγ1. PPARγ has multiple domains including the A/B domain, ligand-independent activation function 1 (AF-1), DNA-binding domain (DBD), ligand-binding domain (LBD), and ligand-dependent activation function 2 (AF-2). Positions of the phosphorylation (P), SUMOylation (S), ubiquitination (Ub), and acetylation (Ac) sites are marked with the functions and the numbers correspond to amino acid position in PPARγ2.
